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Publications

Identification and in vitro characterization of C05-01, a PBB3 derivative with improved affinity for alpha-synuclein
Patricia Miranda-Azpiazua, Marie Svedberga, Makoto Higuchib, Maiko Onob, Zhisheng Jiaa,Dan Sunnemarkc, Charles S. Elmoree, Magnus Schoua, Andrea Varronea
Brain Research, 2020 Sep 14; 1749 (2020) 147131 
DOI: https://doi.org/10.1016/j.brainres.2020.147131

Secretagogin is increased in plasma from type 2 diabetes patients and potentially reflects stress and islet dysfunction
Sara F Hansson, Alex-Xianghua Zhou, Paulina Vachet, Jan W Eriksson, Maria J Pereira, Stanko Skrtic, Helen Jongsma Wallin, Anders Ericsson-Dahlstrand, Daniel Karlsson, Andrea Ahnmark, Maria Sörhede Winzell, Maria Chiara Magnone, Pia Davidsson
PLoS One. . 2018 Apr 27;13(4):e0196601
DOI: https://doi.org/10.1371/journal.pone.0196601

Myeloperoxidase-immunoreactive cells are significantly increased in brain areas affected by neurodegeneration in Parkinson’s and Alzheimer’s disease
Sandra Gellhaar, Dan Sunnemark, Håkan Eriksson, Lars Olson & Dagmar Galter
Cell and Tissue Research. 2017 May 02; volume 369, pages 445–454(2017)
DOI: https://doi.org/10.1007/s00441-017-2626-8

MARK4 and MARK3 associate with early tau phosphorylation in Alzheimer’s disease granulovacuolar degeneration bodies
Harald Lund, Elin Gustafsson, Anne Svensson, Maria Nilsson, Margareta Berg, Dan Sunnemark, and Gabriel von Euler
Acta Neuropathol Commun. 2014; 2: 22
DOI: https://doi.org/10.1186/2051-5960-2-22

Pharmacological inhibition of the chemokine receptor CX3CR1 attenuates disease in a chronic-relapsing rat model for multiple sclerosis
Anna Ridderstad Wollberg, Anders Ericsson-Dahlstrand, Anders Juréus, Petra Ekerot, Sylvia Simon, Maria Nilsson, Stig-Johan Wiklund, Anna-Lena Berg, Mats Ferm, Dan Sunnemark, and Rolf Johansson
PNAS April 8, 2014 111 (14) 5409-5414
DOI: https://doi.org/10.1073/pnas.1316510111

Elevated MARK2-dependent phosphorylation of Tau in Alzheimer's disease
Gucci Jijuan Gu 1, Di Wu, Harald Lund, Dan Sunnemark, Alexander J Kvist, Roy Milner, Sonia Eckersley, Lars N G Nilsson, Karin Agerman, Ulf Landegren, Masood Kamali-Moghaddam
J Alzheimers Dis. 2013 Jan;33(3):699-713
DOI: https://pubmed.ncbi.nlm.nih.gov/23001711/

Role of Individual MARK Isoforms in Phosphorylation of Tau at Ser262 in Alzheimer’s Disease
Gucci Jijuan Gu, Harald Lund, Di Wu, Andries Blokzijl, Christina Classon, Gabriel von Euler, Ulf Landegren, Dan Sunnemark & Masood Kamali-Moghaddam
Neuro Molecular Medicine. 2013 May 12, volume 15, pages458–469(2013)
DOI: https://doi.org/10.1007/s12017-013-8232-3

Tau-tubulin kinase 1 expression, phosphorylation and co-localization with phospho-Ser422 tau in the Alzheimer's disease brain
Harald Lund 1, Richard F Cowburn, Elin Gustafsson, Kia Strömberg, Anne Svensson, Leif Dahllund, David Malinowsky, Dan Sunnemark
Brain Pathol.  2013 Jul;23(4):378-89.
DOI: https://doi.org/10.1111/bpa.12001

Characterization of AZD4694, a novel fluorinated Abeta plaque neuroimaging PET radioligand
Anders Juréus 1, Britt-Marie Swahn, Johan Sandell, Fredrik Jeppsson, Allan E Johnson, Peter Johnström, Jan A M Neelissen, Dan Sunnemark, Lars Farde, Samuel P S Svensson
J Neurochem. 2010 Aug;114(3):784-94.
DOI: https://doi.org/10.1111/j.1471-4159.2010.06812.x

Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanisms of MOG-induced EAE
Sana Eltayeb, Anna-Lena Berg, Hans Lassmann, Erik Wallström, Maria Nilsson, Tomas Olsson, Anders Ericsson-Dahlstrand and Dan Sunnemark
Journal of Neuroinflammation 2007 May 7, 4:14
DOI: https://doi.org/10.1186/1742-2094-4-14

Distribution of the voltage-gated sodium channel Na(v)1.7 in the rat: expression in the autonomic and endocrine systems
Anne Morinville, Bengt Fundin, Luc Meury, Anders Juréus, Kristian Sandberg, Johannes Krupp, Sultan Ahmad, Dajan O'Donnell
J Comp Neurol. 2007 Oct 20;504(6):680-9
DOI: https://doi.org/10.1002/cne.21484

CX3CL1 (fractalkine) and CX3CR1 expression in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis: kinetics and cellular origin
Dan Sunnemark, Sana Eltayeb, Maria Nilsson, Erik Wallström, Hans Lassmann, Tomas Olsson, Anna-Lena Berg and Anders Ericsson-Dahlstrand
Journal of Neuroinflammation, 2005 July 19; 2:17
DOI: https://doi.org/10.1186/1742-2094-2-17

EP3 and EP4 receptor mRNA expression in peptidergic cell groups of the rat parabrachial nucleus
D Engblom, M Ek, A Ericsson-Dahlstrand, A Blomqvist
Neuroscience, 2004; 126(4):989-99
DOI: https://doi.org/10.1016/j.neuroscience.2004.03.042

Effector stage CC chemokine receptor-1 selective antagonism reduces multiple sclerosis-like rat disease
Sana Eltayeb, Dan Sunnemark, Anna-Lena Berg, Gunnar Nordvall, Asa Malmberg, Hans Lassmann, Erik Wallström, Tomas Olsson, Anders Ericsson-Dahlstrand
J Neuroimmunol. 2003 Sep; 142(1-2):75-85
DOI: https://doi.org/10.1016/S0165-5728(03)00264-9

Induction of microsomal prostaglandin E synthase in the rat brain endothelium and parenchyma in adjuvant-induced arthritis
David Engblom, Monica Ek, Ingela M Andersson, Sipra Saha, Marie Dahlström, Per-Johan Jakobsson, Anders Ericsson-Dahlstrand, Anders Blomqvist
The Journal of Comparative Neurology, 2002, Oct 21; 452(3)205
DOI: https://doi.org/10.1002/cne.10380

Dihydropyrimidinase related protein‐2 as a biomarker for temperature and time dependent post mortem changes in the mouse brain proteome
Bo Franzén, Yang Yang,  Dan Sunnemark, Monica Wickman, Jan Ottervald, Madalina Oppermann, Kristian Sandberg
Proteomics, 2003 Oct 09; 3(10):1920
DOI: https://doi.org/10.1002/pmic.200300535

Differential expression of the chemokine receptors CX3CR1 and CCR1 by microglia and macrophages in myelin-oligodendrocyte-glycoprotein-induced experimental autoimmune encephalomyelitis
Dan Sunnemark, Sana Eltayeb, Erik Wallström, Lena Appelsved, Åsa Malmberg, Hans Lassmann, Anders Ericsson-Dahlstrand, Fredrik Piehl, Tomas Olsson
Brain Pathol, 2003 Oct;13(4):617-29
DOI: https://doi.org/10.1111/j.1750-3639.2003.tb00490.x

Pathway across the blood–brain barrier
Monica Ek, David Engblom, Sipra Saha, Anders Blomqvist, Per-Johan Jakobsson & Anders Ericsson-Dahlstrand
Nature, 2001 March 22; 410, 430-431 (2001)
DOI: https://doi.org/10.1038/35068632

Activation of prostanoid EP3 and EP4 receptor mRNA‐expressing neurons in the rat parabrachial nucleus by intravenous injection of bacterial wall lipopolysaccharide
David Engblom, Monica Ek, Anders Ericsson‐Dahlstrand, Anders Blomqvist
The Journal of Comparative Neurology, 2001, Nov 1; 440(4):378 
DOI: https://doi.org/10.1002/cne.1391

Published customer studies where Offspring have provided experimental support

Neurturin and a GLP-1 Analogue Act to Alleviate Diabetes in Zucker Diabetic Fatty Rats
James L Trevaskis, Chester Bittencourt Sacramento, Hani Jouihan, Safina Ali, John Le Lay 2, Stephanie Oldham 2, Nicholas Bhagroo 2, Brandon B Boland 2, Jennifer Cann 3, Yuan Chang 4, Terrence O'Day 5, Victor Howard 2, Christina Reers 6, Maria Sorhede Winzell 7, David M Smith 8, Michael Feigh 9, Pernille Barkholt 9, Kay Schreiter 6, Matthias Austen 6, Uwe Andag 6, Simon Thompson 10, Lutz Jermutus 11, Matthew P Coghlan 11, Joseph Grimsby 2, Cord Dohrmann 6, Christopher J Rhodes 2, Cristina M Rondinone 2, Arun Sharma 2
Diabetes. 2017 Jul;66(7):2007-2018
DOI: https://doi.org/10.2337/db16-0916