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Offspring assist AstraZeneca in project aimed to validate a potential novel biomarker for beta cell stress and dysfunction in type 2 diabetes

In a recently published study in Plos One, a research team led by Dr Sara Hansson at AstraZeneca presented data which demonstrate that secretagogin, an intracellular calcium-binding intracellular protein highly enriched in pancreatic islets, may serve as biomarker in the blood for beta cell dysfunction in individuals with type 2 diabetes (T2D). Offspring supported this project by performing multiplexed immunofluorescence-based detection of secretagogin selectively within the insulin and glucagon-producing cells. Quantitative analysis of the secretagogin staining showed enhanced levels of the protein in the beta cells in the T2D patients.